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Open Targets Platform

A public-private initiative to generate evidence on the validity of therapeutic targets based on genome-scale experiments and analysis.

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Overview

The Open Targets Platform is a comprehensive and robust data integration platform for systematic drug target identification and prioritisation. It integrates evidence from public-domain data sources, including genetics, genomics, transcriptomics, drugs, animal models, and scientific literature, to build and score target-disease associations. The platform is a freely available resource that is actively maintained with quarterly data updates. Data is available through an intuitive user interface, an API, and data downloads. The pipeline and infrastructure codebases are open-source, allowing for the creation of self-hosted private instances with custom data.

✨ Key Features

  • Target-disease association scoring
  • Integration of genetic and genomic data
  • Evidence visualization
  • Open-source platform and codebase
  • API for programmatic access
  • Data downloads

🎯 Key Differentiators

  • Public-private partnership model
  • Focus on evidence scoring for target-disease associations
  • Completely open-source and freely available

Unique Value: Provides a comprehensive, evidence-based, and freely accessible resource to de-risk and accelerate drug discovery by systematically identifying and prioritizing therapeutic targets.

🎯 Use Cases (3)

Drug target identification and prioritization Exploring the genetic basis of diseases Validating therapeutic hypotheses

✅ Best For

  • Systematic drug target identification in pharmaceutical research

💡 Check With Vendor

Verify these considerations match your specific requirements:

  • Clinical trial management

🏆 Alternatives

DisGeNET GeneCards

Unlike many other databases, Open Targets provides a scoring system to rank target-disease associations and is a collaborative effort between major pharmaceutical companies and academic institutions, ensuring its relevance to drug discovery pipelines.

💻 Platforms

Web API

🔌 Integrations

Reactome Expression Atlas UniProt ChEMBL GWAS Catalog Europe PMC

🛟 Support Options

  • ✓ Email Support
  • ✓ Dedicated Support (NA tier)

💰 Pricing

Contact for pricing
Free Tier Available

Free tier: The entire platform and its data are freely available for public and private use.

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